Polygenic risk scores in epilepsy

Abstract An epilepsy diagnosis has large consequences for an individual but is often difficult to make in clinical practice. Novel biomarkers are thus greatly needed. Here, we give overview of how thousands common genetic factors that increase the risk can be summarized as polygenic scores (PRS). We discuss current state research on PRS serve a biomarker epilepsy. The high heritability forms epilepsy, particularly generalized indicates promising potential and prediction. Small sample sizes low ancestral diversity genome-wide association studies show, however, need larger more diverse before could properly implemented clinic.